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December 8, 2025Blood

Germline predisposition in pediatric malignancies: Insights from a retrospective study at Dana-Farber Cancer Institute

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Authors

JKJunne KamiharaJKJennifer C. KesselheimRRR. Grant Rowe

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Overview

Retrospective study reveals 23% germline predisposition in pediatric hematologic malignancies, suggesting genetic counseling and testing improve treatment decisions.

Key Points

  • 48% of patients who underwent genetic counseling had a pathogenic variant detected, indicating significant germline involvement.
  • The cohort included 571 patients with hematologic malignancies, primarily affecting children and young adults.
  • Germline testing led to treatment adjustments, including hematopoietic stem cell transplantation for two patients identified with germline variants.
  • The findings suggest enhanced surveillance practices for pediatric malignancies are warranted based on genetic predisposition.

Cite This Study

Kamihara et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5bbhttps://doi.org/10.1182/blood-2025-3213
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance and clinical utility of germline genetic testing criteria for predisposition to myeloid neoplasms in adults2025
  2. 2Low utilization of cancer genetics referrals in newly diagnosed Acute Myeloid Leukemia2025
  3. 3Insights into germline predisposition to pediatric lymphoid malignancies2025 · 2 citations
  4. 4Implementing a Genetic Counselor‐Led Model for Hereditary Myeloid Malignancies: A Real‐World Study2025
  5. 5Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition2025