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September 12, 2025Frontiers in GeneticsOpen Access

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition

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Authors

GÖGizem ÖnderÖÖÖzkan ÖzdemirFTFulya Taylan

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Overview

Germline sequencing identified cancer predisposition variants in children with leukemia, highlighting implications for genetic counseling.

Key Points

  • Identifying germline variants can optimize clinical management of leukemia and lymphoma in children with familial cancer syndromes.
  • Deep clinical-genomic correlation revealed 13 relevant germline variants in known cancer predisposition genes, aiding in diagnostic refinement.
  • Targeted sequencing in a Turkish cohort of 36 individuals highlighted novel candidate variants and revealed familial patterns associated with multiple malignancies.
  • These findings underscore the importance of genetic counseling for surveillance and risk assessment in families with high consanguinity.

Cite This Study

Önder et al. (2025) studied this question.

synapsesocial.com/papers/68d41eca713b0b5dfea6779bhttps://doi.org/10.3389/fgene.2025.1624306
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Germline Variant Burden Warrants Universal Genetic Testing in Pediatric Myeloid Leukemia2025
  2. 2Germline predisposition in pediatric malignancies: Insights from a retrospective study at Dana-Farber Cancer Institute2025
  3. 3Insights into germline predisposition to pediatric lymphoid malignancies2025
  4. 4A landscape of genetic heterogeneity in germline predisposition to familial chronic lymphocytic leukemia2025
  5. 5Intermediate and high-risk clonal hematopoiesis in germline predisposition families2025