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December 8, 2025BloodOpen Access

Low utilization of cancer genetics referrals in newly diagnosed Acute Myeloid Leukemia

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Authors

TBTehilla BranderMRMichelle RudshteynMKMarina Kremyanskaya

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Overview

Retrospective review shows low cancer genetics referral rate in acute myeloid leukemia, highlighting urgent need for increased awareness in clinical genetics.

Key Points

  • Only 6.6% of patients who met genetics referral criteria were actually referred to cancer genetics services.
  • Retrospective analysis of newly diagnosed acute myeloid leukemia patients revealed significant underutilization of cancer genetics referrals.
  • Cancer genetics referral guidelines emphasize the importance of hereditary factors in acute myeloid leukemia and myeloproliferative neoplasms.
  • Raising awareness and ensuring education for healthcare providers may improve the rates of referral for genetic evaluation.

Cite This Study

Brander et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd4ahttps://doi.org/10.1182/blood-2025-1085
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Germline predisposition in pediatric malignancies: Insights from a retrospective study at Dana-Farber Cancer Institute2025
  2. 2Implementing a Genetic Counselor-Led Model for Hereditary Myeloid Malignancies: A Real-World Study.2025
  3. 3Performance and clinical utility of germline genetic testing criteria for predisposition to myeloid neoplasms in adults2025
  4. 4Selective germline testing in multiple myeloma patients yields a six-fold increase in actionable cancer predisposition findings: Time for screening guidelines?2025 · 1 citations
  5. 5Data from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025