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December 8, 2025BloodOpen Access

Distinct distributions of lymphocyte subsets in myelodysplastic syndrome correlate with risk stratification

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Authors

XLXinguang Liu

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Overview

Cohort study reveals immune dysregulation in myelodysplastic syndrome, indicating risk stratification implications.

Key Points

  • Immune dysregulation characterized MDS with distinct lymphocyte subset distributions, impacting risk.
  • Significant changes in lymphocyte subsets were observed in hematopoietic stem cells of MDS patients.
  • Cohort study included 54 newly diagnosed MDS patients and 17 healthy controls for comparison.
  • Results suggest marked immune variations correlate with MDS risk stratification, warranting further exploration.

Cite This Study

Xinguang Liu (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d502https://doi.org/10.1182/blood-2025-7361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From chaos to clarity? decoding the inflammatory profiles in lower-risk MDS2025
  2. 2Bone marrow immune and stromal niche remodeling in myelodysplastic neoplasm patients under erythropoietic therapies by 29-color full-spectrum flow cytometry2025
  3. 3Immunological biomarkers and TARC/CCL17 in myelodysplastic syndrome: Insights into immune microenvironment regulation2025
  4. 4Prognostic Impact of Lymphocyte to Monocyte Ratio in Patients with Myelodysplastic Neoplasms/Syndromes2025
  5. 5Searching for a myelodysplastic syndrome stem cells (MDS-SCs) signature by flow cytometry: Toward a new prognostic tool?2025 · 1 citations