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December 8, 2025Blood

Bone marrow immune and stromal niche remodeling in myelodysplastic neoplasm patients under erythropoietic therapies by 29-color full-spectrum flow cytometry

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Authors

CJClàudia Pellín JouPAPamela AchaAGAna Pérez González

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Overview

Treatment modulates immune remodeling and hematologic response in patients with myelodysplastic neoplasms, suggesting tailored therapeutic approaches.

Key Points

  • Treatment results in significant remodeling of the bone marrow microenvironment following 6 months of erythropoietic therapies.
  • Endothelial progenitor cells and mesenchymal stromal cells showed distinct changes in response to treatment with TGF-β ligand traps.
  • Immune profiling revealed notable shifts in myeloid-derived suppressor cells and dendritic cell populations after therapy.
  • Findings highlight the importance of immune architecture modulation for improving clinical outcomes in myelodysplastic neoplasms.

Cite This Study

Jou et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d821https://doi.org/10.1182/blood-2025-3183
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