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December 8, 2025Blood

Retention of immunosuppressive C1Q macrophages following therapeutic interventions imparts negative outcomes across human multiple myeloma studies

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Authors

JEJoshua EpsteinCSChang-Xin ShiKPKirsten Pfeffer

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Overview

Observational analysis shows that persistent C1Q macrophages in multiple myeloma indicate poorer outcomes, suggesting their role in therapeutic resistance.

Key Points

  • C1Q macrophages' presence correlates with inferior clinical outcomes in multiple myeloma after therapy.
  • Analysis across 56 human bone marrow samples reveals distinct expression features in macrophages during progression.
  • Integration of single-cell datasets highlights the critical role of rare cell populations in the tumor microenvironment.
  • The findings suggest potential therapeutic targets by understanding the immune response and macrophage behavior.

Cite This Study

Epstein et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4cehttps://doi.org/10.1182/blood-2025-7481
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surface protein-focused gene expression analysis identifies prognostic immunophenotypes in newly diagnosed multiple myeloma2025
  2. 2Kinetics of circulating multiple myeloma cells (CMMCs) in patients undergoing standard-of-care anti-BCMA chimeric antigen receptor T cell therapy for Relapsed/Refractory multiple myeloma2025 · 1 citations
  3. 3Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma2025
  4. 4Spatial multiomics reveal a critical role for TIM4-expressing macrophages in blast transformation of chronic myelomonocytic leukemia2025
  5. 5Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis2025