December 8, 2025Blood

Ferritin reference ranges and improving diagnosis of iron deficiency without anemia

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Authors

SCSteven W. CottenUniversity of North Carolina at Chapel Hill SWSamuel WilsonUniversity of North Carolina at Chapel Hill CBCallie BerkowitzUniversity of North Carolina at Chapel Hill

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Implication

Observational analysis reveals discrepancies in ferritin thresholds affecting diagnosis of iron deficiency without anemia, indicating gaps in treatment strategies.

Key Points

Nearly one-third of patients had ferritin levels below 30ng/mL yet above current lower limits of normal.
Clinical data extracted from 228 patients showed 19% had iron deficiency anemia and 16% had iron deficiency without anemia.
Utilization of electronic health records allowed classification of patients based on ferritin thresholds and hemoglobin levels.
This analysis highlights a need for harmonization of ferritin assay thresholds to improve diagnosis and treatment of iron deficiency.

Cite This Study

Cotten et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3a7 https://doi.org/10.1182/blood-2025-2609

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Implication

Observational analysis reveals discrepancies in ferritin thresholds affecting diagnosis of iron deficiency without anemia, indicating gaps in treatment strategies.

Ferritin reference ranges and improving diagnosis of iron deficiency without anemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Ferritin reference ranges and improving diagnosis of iron deficiency without anemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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