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December 8, 2025BloodOpen Access

Pre-diagnostic biomarkers show disease susceptibility continuum and enable early prediction of multiple myeloma

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Authors

JXJiadai XuBLBingjie LiZYZhigang Yao

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Overview

Prospective cohort analysis shows biomarkers predict multiple myeloma risk, suggesting new screening strategies for at-risk individuals.

Key Points

  • This research aims to identify biomarkers that can predict the onset of multiple myeloma in individuals.
  • Prospective cohort study using UK Biobank data with 501,967 participants and 12.8 years follow-up.
  • Biomarkers were analyzed: anemia markers (hemoglobin, reticulocyte count), renal function markers (cystatin C), and protein markers (hypoalbuminemia).
  • Statistical analyses implemented include Cox proportional hazards models and multivariate analysis.
  • All eight biomarkers showed significant associations with future risk of multiple myeloma onset.
  • Protein markers had the strongest effects, including total protein elevation and albumin/globulin ratio reduction.
  • Time-stratified analysis demonstrated distinct patterns in biomarker abnormalities over a decade before diagnosis.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0aahttps://doi.org/10.1182/blood-2025-2231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression2025
  2. 2Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin2025
  3. 3Prognostic impact of early disease progression and early mortality in patients with multiple myeloma: a real-world cohort study2026
  4. 4AI-based analysis reveals novel blood protein biomarkers for predicting cardiac amyloidosis approximately a decade early: A UK biobank study2025
  5. 5A Multivariable Prediction Model for Early Mortality in Multiple Myeloma Patients With Renal Impairment2025