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December 4, 2025npj Precision OncologyOpen Access

Characterizing circulating rare cells in peripheral blood for detecting and monitoring multiple myeloma and precursor states

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Authors

SSStephanie N. ShishidoJMJeremy MasonMKMohamed Kamal

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Overview

Analysis using liquid biopsy and multivariate modeling shows distinct plasma cell profiles in multiple myeloma patients, improving detection.

Key Points

  • Liquid biopsy effectively characterizes circulating plasma cells, indicating disease progression and monitoring.
  • Distinct plasma cell profiles identified through multivariate modeling with enhanced accuracy of 86%.
  • Assessment was conducted on samples from patients diagnosed with multiple myeloma and its precursor states.
  • Using peripheral blood minimizes invasive procedures and highlights the potential of liquid biopsy for clinical applications.

Cite This Study

Shishido et al. (2025) studied this question.

synapsesocial.com/papers/6930e8cdea1aef094cca37eehttps://doi.org/10.1038/s41698-025-01175-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression2025
  2. 2Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin2025
  3. 3Phenotypic evolution of circulating tumor plasma cells across MGUS, SMM and multiple myeloma2025
  4. 4Highly multiplexed imaging recovers immune and metabolic niches in multiple myeloma associated with disease progression and bone involvement2025 · 1 citations
  5. 5Peripheral circulating myeloma cells accurately identify bone marrow MRD positivity in multiple myeloma patients receiving CAR T or autologous transplant2025