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December 8, 2025Blood

DDX3X facilitates adaption to proteotoxic stress by regulating the translation of MAPKAPK2 and the stability of TMCO1 via stress granules in multiple myeloma

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Authors

ENEnqi NiCSChunyan Sun

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Overview

Analysis shows DDX3X regulates translation and stability of MAPKAPK2 and TMCO1 in multiple myeloma, suggesting targeting DDX3X may enhance treatment.

Key Points

  • DDX3X modulates cell homeostasis under proteotoxic stress, enhancing multiple myeloma survival.
  • Knockdown of DDX3X via doxycycline increased apoptosis and reduced tumor size in murine models.
  • Investigation used eCLIP-seq and RIP-qPCR to establish DDX3X interactions with target mRNAs.
  • Combining DDX3X inhibition with proteasome inhibitors could improve therapeutic outcomes in multiple myeloma.

Cite This Study

Ni et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d355https://doi.org/10.1182/blood-2025-3944
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PSMD3 orchestrates metabolic reprogramming and immunogenic cell death in multiple myeloma2025
  2. 2DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance2025
  3. 3Tryptophan metabolism plays a significant role in multiple myeloma survival2025
  4. 4DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance2025 · 6 citations
  5. 5FBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells2025