Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Tryptophan metabolism plays a significant role in multiple myeloma survival

View Full Paper
Ask AI
Bookmark
Share

Authors

JRJulia Grace ReinkeKCKanita ChaudhryPPPeng Peng

Discussion

Loading...

Member takes

Overview

Observational analysis reveals reduced progression-free survival in multiple myeloma linked to kynurenine and tryptophan metabolism alterations.

Key Points

  • Tryptophan metabolism significantly impacts multiple myeloma cell survival and proliferation, enhancing resistance to treatment.
  • CoMMpass data shows patients with higher TDO expression have lower progression-free survival rates.
  • Analysis of multiple myeloma cell lines indicates TDO and AHR signaling play crucial roles in survival mechanisms.
  • Highlighting the potential of targeting tryptophan metabolism for improved therapies in multiple myeloma, especially in refractory cases.

Cite This Study

Reinke et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d674https://doi.org/10.1182/blood-2025-5726
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tryptophan metabolism and the plasma cell/multiple myeloma microenvironment 39072025
  2. 2Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma2025 · 2 citations
  3. 3Indole-related metabolites suppress the anti-tumor function of CD8+ T cells in the bone marrow microenvironment of multiple myeloma2025
  4. 4DDX3X facilitates adaption to proteotoxic stress by regulating the translation of MAPKAPK2 and the stability of TMCO1 via stress granules in multiple myeloma2025
  5. 5Single-cell and bulk transcriptomics uncovers PRKD2-driven tumor stemness and progression in multiple myeloma2025 · 1 citations