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December 8, 2025BloodOpen Access

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

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Authors

WLWei LiHZHonghai ZhangDLDong Lei

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Overview

Analysis shows DDX6 influences chemosensitivity and metabolic plasticity in acute myeloid leukemia, highlighting its phase separation's role.

Key Points

  • Chemoresistance is affected by DDX6 knockout, enhancing chemosensitivity in acute myeloid leukemia.
  • A focused CRISPR library pinpointed DDX6 as critical for regulating metabolic plasticity and stress granule dynamics.
  • Observational analysis revealed phase separation is crucial for DDX6 function in leukemia development and chemotherapy response.
  • These findings suggest targeting DDX6 may improve treatment strategies by altering metabolic responses in AML.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4fehttps://doi.org/10.1182/blood-2025-212
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