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December 8, 2025BloodOpen Access

RNA-sequencing improves risk stratification and guides treatment decision-making in acute lymphoblastic leukemia- a UK single centre experience

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Authors

RGRajeev GuptaKXKe Xu

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Overview

Retrospective analysis shows that RNA sequencing improves risk stratification and informs treatment decisions in acute lymphoblastic leukemia patients, highlighting clinical relevance of fusion genes.

Key Points

  • This research aims to evaluate the impact of RNA sequencing on risk stratification and treatment decision-making in acute lymphoblastic leukemia patients.
  • Retrospective review of clinical and molecular data from 121 ALL patients diagnosed between 2021-2025.
  • Assessment of RNA-seq impact on risk classification, MRD assay design, and treatment decisions.
  • Use of targeted sequencing panels to identify fusion genes and compare with traditional FISH testing.
  • RNA sequencing identified 38 gene fusions in 35 patients, improving risk stratification for 5% of cases.
  • 20% of treatment decisions were influenced by RNA sequencing findings, notably regarding fusion genes.
  • Standard FISH testing alone missed several crucial fusions detected by RNA sequencing.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d20ehttps://doi.org/10.1182/blood-2025-6878
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application of Targeted RNA‐Sequencing in High‐Risk B‐Cell Acute Lymphoblastic Leukemia (B‐ALL): Identifying Fusions, IKZF1 Deletions, and CRLF2 Expression in an Indian Cohort2025
  2. 2RNA‐seq Molecular Risk Classification Refines Prognostic Stratification in Childhood B‐Cell Acute Lymphoblastic Leukemia Treated With the CCCG‐ALL‐2020 Protocol: A Real‐World Cohort Study2026
  3. 3DNA sequencing outperforms RNA sequencing for comprehensive fusion detection in lymphoma diagnostics2025
  4. 4Comprehensive DNA/RNA-based targeted sequencing for molecular karyotyping and clonality assessment in newly diagnosed multiple myeloma patients2025
  5. 5Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome Sequencing2025