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December 8, 2025Blood

Myelodysplastic/myeloproliferative overlap neoplasms: Clinicopathological features, treatment strategies, and outcomes — a UK multicentre cohort Study

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Authors

AAAhmad AlabdulkarimACAdrian ChoyDADelphine Appadurai

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Overview

Multicentre cohort study shows treatment challenges and poor survival in patients with myelodysplastic/myeloproliferative overlap neoplasms, indicating urgent need for better strategies.

Key Points

  • To evaluate clinicopathological features, treatment strategies, and outcomes of patients with MDS/MPN in UK.
  • Conducted chart reviews using electronic records across 17 UK centres
  • Defined MDS/MPN according to WHO2022 classification
  • Analyzed baseline demographics, molecular profiles, and clinical outcomes using descriptive statistics
  • Identified 89 MDS/MPN patients with a median OS of 28.9 months
  • MDS/MPN-N showed the shortest OS at 11 months
  • Anaemia at diagnosis was linked to worse OS (22.8 months) compared to non-anaemic patients (31.2 months)

Cite This Study

Alabdulkarim et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d20ahttps://doi.org/10.1182/blood-2025-7365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience2025
  2. 2Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025
  3. 3Mutational Spectrum and Clinical Outcomes of Myelodysplastic/Myeloproliferative Neoplasms: A Single-Institution Study in Korea with Emphasis on U2AF12025 · 1 citations
  4. 4Clinical, genetic, and pathologic differences across race, ethnicity, and sex in patients with MDS and precursor conditions from the national MDS natural history study2025
  5. 5Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression2025