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October 9, 2025Journal of Clinical MedicineOpen Access

Mutational Spectrum and Clinical Outcomes of Myelodysplastic/Myeloproliferative Neoplasms: A Single-Institution Study in Korea with Emphasis on U2AF1

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Authors

MPMin‐Seung ParkDCDae-Ho ChoiJJJun Ho Jang

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Overview

Retrospective analysis reveals U2AF1 mutations and overall survival trends in MDS/MPN patients.

Key Points

  • U2AF1 mutations were identified as a significant prognostic factor, indicating potential adverse outcomes.
  • ASXL1 mutations were found in 52.8% of patients, with a significant association with better prognosis in CMML cases.
  • Transfusion dependency was linked to poor prognosis, with a hazard ratio of 7.78, highlighting its clinical importance.
  • The study provides insights into the mutational spectrum and prognosis of MDS/MPNs based on Korean patient data.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee60cdhttps://doi.org/10.3390/jcm14197074
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