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December 8, 2025BloodOpen Access

Autoimmune hemolytic anemia (AIHA) associated with human immunodeficiency virus (HIV) infection: Two challenging cases

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Authors

CNCharlotte NaworNMNoah MehrFAFatima Aldarweesh

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Overview

Case reports reveal complexities of autoimmune hemolytic anemia in HIV patients, highlighting transfusion difficulties and poor outcomes.

Key Points

  • To evaluate the management challenges of autoimmune hemolytic anemia (AIHA) in patients with HIV.
  • Presented two case reports of patients with HIV and AIHA
  • Analyzed laboratory findings including hemoglobin, haptoglobin, and DAT results
  • Described treatment interventions including immunosuppressive therapy and plasma exchange
  • Patients presented with severe anemia and diagnosed with AIHA
  • Complications included difficulties in blood bank testing and transfusion
  • Both patients died shortly after admission despite aggressive treatment

Cite This Study

Nawor et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d172https://doi.org/10.1182/blood-2025-6441
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fatal Cytokine Collision: HLH–AIHA in Advanced AIDS—Case Report and Literature Review2025
  2. 2Autoimmune hemolytic anemia with an initially negative direct antiglobulin test: A diagnostic challenge2025
  3. 3Severe Warm Autoimmune Hemolytic Anemia With Profound Anemia Requiring Multimodal Immunosuppressive Therapy2026
  4. 4Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association2025
  5. 5Safety of red blood cell transfusion despite serologic incompatibility in autoimmune hemolytic anemia: A real-world multicenter study2026