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December 8, 2025Blood

Diagnostic challenges in systemic light chain( AL) amyloidosis: A retrospective evaluation of biopsy yeild and typing strategies in an Indian tertiary care centre

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Authors

NSNeeraj SidharthanAHAparna HariGGGeorg Gutjahr

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Overview

Retrospective analysis reveals low diagnostic yield of surrogate biopsies in AL amyloidosis, suggesting the need for better typing methods.

Key Points

  • To evaluate biopsy strategies and diagnostic yield for patients suspected of having AL amyloidosis.
  • Retrospective study of patients between 2002 and 2024
  • Identified cases through electronic records
  • Categorized patients by predominant organ involvement
  • Assessed histopathology findings and biopsy yield
  • Used descriptive statistics and R software for analysis.
  • 184 patients included with a median age of 59 years
  • 74% showed amyloid deposition after biopsy
  • 74% sensitivity for target organ biopsies; 40% for surrogate sites
  • Kidney biopsies had a diagnostic yield of 87%
  • 14% of biopsy-positive patients underwent amyloid typing.

Cite This Study

Sidharthan et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfe2https://doi.org/10.1182/blood-2025-8140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Presenting features, treatment patterns and predictors of outcomes in AL amyloidosis at a tertirary care cancer centre2025
  2. 2Limited diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis: A single institution's experience2025
  3. 3Beyond the Usual Suspects: Clinical and Pathological Insights From a Rare Case of Light Chain (AL) Amyloidosis in a Filipino Patient2025
  4. 4Difficulties in diagnosing and treating AL amyloidosis: a case from practice2025
  5. 5Cardiac light-chain amyloidosis: a clinical update2026