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December 8, 2025BloodOpen Access

Limited diagnostic utility of abdominal fat pad biopsy for systemic amyloidosis: A single institution's experience

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Authors

MOMark OliverTSTimothy SchmidtDYDavid Yang

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Overview

Retrospective review reveals only 9% sensitivity of abdominal fat pad biopsy for systemic amyloidosis, suggesting further standardization needed.

Key Points

  • Abdominal fat pad biopsy showed only 9% sensitivity for systemic amyloidosis, indicating limited utility as a diagnostic tool.
  • Of 48 biopsies, 46 (96%) were negative, highlighting the challenge in accurate diagnosis.
  • Retrospective review of biopsy data from a single institution over 27 months identified key clinical outcomes.
  • Quality control confirmed 100% agreement in negative samples, underscoring the need for standardized biopsy protocols.

Cite This Study

Oliver et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da77https://doi.org/10.1182/blood-2025-2788
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