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December 8, 2025Blood

Real-world treatment patterns and survival outcomes in primary CNS lymphoma: Analysis of the national cancer database

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Authors

JAJithma P. AbeykoonMTMazie TsangJMJavier Muñoz

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Overview

Analysis reveals chemotherapy and ASCT improve survival in primary CNS lymphoma, highlighting key disparities.

Key Points

  • This research aims to analyze treatment patterns and survival outcomes in patients with primary CNS lymphoma (PCNSL).
  • Data from the National Cancer Database for PCNSL patients diagnosed between 2004 and 2020 was analyzed.
  • Descriptive statistics for demographics and treatment characteristics were performed.
  • Survival outcomes were estimated using the Kaplan-Meier method and compared using log-rank tests.
  • Multivariable Cox proportional hazards models identified predictors of overall survival.
  • The median overall survival for PCNSL patients was 17.4 months.
  • Chemotherapy followed by autologous stem cell transplant led to the best survival outcomes.
  • African American patients had poorer median overall survival compared to other races.
  • Treatment at an academic center correlated with longer survival times.

Cite This Study

Abeykoon et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf94https://doi.org/10.1182/blood-2025-4494
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unequal outcomes: The role of institutional setting in the management of primary CNS lymphoma2025 · 1 citations
  2. 2Evaluation of treatment regimens and prognostic factors in primary central nervous system lymphomas2025 · 1 citations
  3. 3Patient characteristics, treatment patterns, and outcomes in primary CNS lymphoma of T-cell origin: A multi-institution retrospective analysis2025
  4. 4When location meets biology: combined risk patterns drive outcomes in primary central nervous system lymphoma2025 · 1 citations
  5. 5Treatment patterns and outcomes of primary central nervous system lymphoma treated with high-dose methotrexate with or without autologous stem cell transplantation or whole brain radiation in the rea-world setting2025