Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Treatment patterns and outcomes of primary central nervous system lymphoma treated with high-dose methotrexate with or without autologous stem cell transplantation or whole brain radiation in the rea-world setting

View Full Paper
Ask AI
Bookmark
Share

Authors

YPYifan PangCHC. H. W. HorneNSNicole Serapin

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows improved progression-free survival in lymphoma patients receiving autologous stem cell transplantation, indicating effective treatment options.

Key Points

  • Patients receiving autologous stem cell transplantation had a 100% progression-free survival rate.
  • Induction chemotherapy using high-dose methotrexate achieved an overall response rate of 80%.
  • The retrospective analysis focused on patients diagnosed with non-Hodgkin lymphoma, primarily diffuse large B-cell lymphoma.
  • Results support the efficacy of high-dose methotrexate, emphasizing the need for timely treatment initiation.

Cite This Study

Pang et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0behttps://doi.org/10.1182/blood-2025-8064
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative analysis of consolidation strategies after induction chemotherapy in primary central nervous system lymphoma2025
  2. 2Consolidation (Cons) and maintenance (Maint) approaches in primary central nervous system lymphoma (PCNSL) after high-dose methotrexate induction in transplant-ineligible patients2025
  3. 3Outcomes of primary CNS lymphoma treated with combined immunochemotherapy with whole-brain radiotherapy2025
  4. 4Salvage whole brain radiotherapy after methotrexate failure in primary cns lymphoma2025
  5. 5Management of Newly Diagnosed Primary Central Nervous System Lymphoma2025