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December 8, 2025Cancer Research

Abstract A031: Multi-omics profiling reveals cancer-relevant gut–liver axis alterations during MASL to MASH transition

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Authors

SGSiem GoitomBMBrigitte MaesJGJessica Gross

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Overview

Multi-omics profiling demonstrates metabolic and hormonal changes in MASLD leading to MASH, suggesting mechanisms for colorectal cancer.

Key Points

  • This research aims to investigate the molecular alterations between metabolic dysfunction-associated steatotic liver disease and its advanced form, metabolic dysfunction-associated steatohepatitis, in relation to cancer.
  • Used male C57BL/6NTac mice to model MASLD and MASH
  • Conducted untargeted metabolomics and lipidomics analysis on liver, colon, and stool samples
  • Measured circulating enteroendocrine hormones and cytokines
  • Assessed hepatic serotonin and fibrotic markers by immunofluorescence
  • Histology confirmed the progression from MASLD to MASH
  • Lipidomics analysis showed stage-specific elevation of lipotoxic species linked to insulin resistance
  • Cholic acid levels increased across disease stages, correlating with colorectal cancer pathways
  • Filtration of EEC hormones showed initial increase in MASLD but not in MASH, correlating with disease progression

Cite This Study

Goitom et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf66https://doi.org/10.1158/1538-7445.canevol25-a031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic, Lipidomic, and Enterohormone Changes in the Progression from MASLD to MASH2025
  2. 2“Trust your gut”: exploring the connection between gut microbiome dysbiosis and the advancement of Metabolic Associated Steatosis Liver Disease (MASLD)/Metabolic Associated Steatohepatitis (MASH): a systematic review of animal and human studies2025
  3. 3Regulatory Role and Biomarker Potential of Gut Microbiota Metabolites in the Progression of Metabolic dysfunction-associated steatotic liver disease (MASLD) to Hepatocellular Carcinoma (HCC)2025
  4. 4Paired snRNA-seq and scRNA-seq analysis of MASLD patients to identify early-stage markers for disease progression2025 · 4 citations
  5. 5MASLD Under the Microscope: How microRNAs and Microbiota Shape Hepatic Metabolic Disease Progression2025 · 3 citations