September 11, 2025Frontiers in NutritionOpen Access

“Trust your gut”: exploring the connection between gut microbiome dysbiosis and the advancement of Metabolic Associated Steatosis Liver Disease (MASLD)/Metabolic Associated Steatohepatitis (MASH): a systematic review of animal and human studies

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Discussion

Systematic review reveals gut microbiome dysbiosis is linked to steatosis and inflammation in MASLD and MASH, suggesting diagnostic potentials.

Gut microbiome dysbiosis is significantly linked to the development of MASLD and MASH, highlighting its crucial role in liver disease.
The synthesis of animal and human studies uncovers associations between microbial metabolites and the progression of hepatic conditions.
Innovative approaches like microbiome profiling and targeted probiotics demonstrate potential diagnostic and therapeutic benefits for liver diseases.
Existing studies indicate gaps in longitudinal research and the need for increased representation of diverse populations.

Bahitham et al. (2025) studied this question.

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Systematic review reveals gut microbiome dysbiosis is linked to steatosis and inflammation in MASLD and MASH, suggesting diagnostic potentials.