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September 20, 2025Open Access

Metabolomic, Lipidomic, and Enterohormone Changes in the Progression from MASLD to MASH

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Authors

JRJaclyn A RivasAMAlexandria C. MurphyPPPraveena Prasad

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Overview

Analysis identifies significant metabolic changes and hormonal responses, suggesting potential therapeutic targets in liver disease.

Key Points

  • Alterations in metabolomic and lipidomic profiles indicate progression from MASLD to MASH in mice.
  • Increased cholic acid was observed in the liver, colon, and stool of MASLD and MASH mice compared to controls.
  • Higher levels of enteroendocrine hormones were noted in MASLD mice, while MASH lacked these changes.
  • These findings imply that hormones may influence the progression from MASLD to MASH and liver fibrosis.

Cite This Study

Rivas et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79e38https://doi.org/10.1101/2025.09.16.676598
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A031: Multi-omics profiling reveals cancer-relevant gut–liver axis alterations during MASL to MASH transition2025
  2. 2Paired snRNA-seq and scRNA-seq analysis of MASLD patients to identify early-stage markers for disease progression2025 · 4 citations
  3. 3MASH: the nexus of metabolism, inflammation, and fibrosis2025
  4. 4“Trust your gut”: exploring the connection between gut microbiome dysbiosis and the advancement of Metabolic Associated Steatosis Liver Disease (MASLD)/Metabolic Associated Steatohepatitis (MASH): a systematic review of animal and human studies2025
  5. 5The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine <scp>MASH</scp> Model2025 · 1 citations