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December 8, 2025COVIDOpen Access

Evaluation of Self-Collected Mouth Rinse Specimens for Coronavirus Disease 2019 Testing: A Pilot Study

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Authors

KFKento FukanoJTJunko S. TakeuchiJTJunko Terada-Hirashima

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Overview

Pilot study finds mouth rinse specimens show 94% sensitivity for COVID-19 in patients with diabetes and salivary reduction, suggesting a reliable alternative.

Key Points

  • To evaluate the diagnostic performance of mouth rinse specimens for RT-qPCR COVID-19 testing as an alternative to saliva.
  • Pilot study involving mouth rinse specimen collection for RT-qPCR testing
  • Comparison of mouth rinse specimens to saliva specimens
  • Analysis of specimens from patients with reduced saliva secretion risk factors
  • Mouth rinse specimens had 96.7% overall agreement with saliva specimens
  • Sensitivity of mouth rinse specimens was 94.1%
  • Specificity was 100%
  • Viral load in mouth rinse specimens was lower than in saliva due to dilution

Cite This Study

Fukano et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236ca29https://doi.org/10.3390/covid5120202
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Also Consider

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  1. 1Saliva Has High Sensitivity and Specificity for Detecting SARS-CoV-2 Compared to Nasal Swabs but Exhibits Different Viral Dynamics from Days of Symptom Onset2025
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  3. 3Sensitivity of gargle samples compared to swabs for SARS-CoV-2 detection with nucleic acid amplification testing: a systematic review and meta-analysis2026
  4. 4Evaluation of alternative clinical samples for the detection of SARS-CoV-2 and influenza virus by automated multiplex RT-PCR2025
  5. 5Clinical Surveillance Identifies SARS-CoV-2 Outbreaks and Emergence of Novel Variants in Real-Time2025