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September 10, 2025The Journal of Infection in Developing CountriesOpen Access

Evaluation of alternative clinical samples for the detection of SARS-CoV-2 and influenza virus by automated multiplex RT-PCR

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Authors

MÖMuhammed Alper ÖzarslanEge UniversityÖPÖmür Mustafa ParkanErciyes UniversityMSMehmet SoyluEge University

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Implication

This study compares various clinical samples for detecting sars-cov-2 and influenza, showing comparable effectiveness.

Key Points

  • The three sample types showed almost perfect agreement for diagnosing sars-cov-2 and influenza A.
  • Favorable overall performance metrics included sensitivity, specificity, and low coefficient of variation (CV ≤ 6%).
  • Self-collected nasal swabs and saliva samples demonstrated comparable results to healthcare professional-collected nasopharyngeal swabs.
  • The ease of self-collection from saliva and nasal swabs may improve access to diagnostic testing for respiratory infections.

Cite This Study

Özarslan et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c6b0https://doi.org/10.3855/jidc.20801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analytical performance evaluation of a multiplex real-time RT-PCR kit for simultaneous detection of SARS-CoV-2, influenza A/B, and RSV2025 · 5 citations
  2. 2A-367 Rapid and Sensitive Real-time RT-PCR Point-of-Care System for Detection and Differentiation of Influenza A and B, RSV, and SARS-CoV-22025
  3. 3Saliva Has High Sensitivity and Specificity for Detecting SARS-CoV-2 Compared to Nasal Swabs but Exhibits Different Viral Dynamics from Days of Symptom Onset2025 · 1 citations
  4. 4Diagnostic accuracy evaluation of a point-of-care antigen test for SARS-CoV-2 and influenza in UK primary care (RAPTOR-C19)2025 · 2 citations
  5. 5Development of rapid diagnostic tests for multiplexed detection of COVID-19 and Influenza diseases2025