September 10, 2025DiagnosticsOpen Access

Saliva Has High Sensitivity and Specificity for Detecting SARS-CoV-2 Compared to Nasal Swabs but Exhibits Different Viral Dynamics from Days of Symptom Onset

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Comparative analysis reveals saliva shows high sensitivity and specificity, while viral dynamics differ in symptomatic individuals.

The saliva test demonstrated a 94% positive percent agreement and 99% negative percent agreement compared to nasal swabs.
Viral load analysis indicated saliva samples decreased beyond day 1, while nasal swabs increased up to day 4 before decreasing.
Among 737 symptomatic participants, the same number of discordant positive samples was found for saliva and nasal swabs within 5 days of symptom onset.
Testing methods that are less invasive, like saliva-based testing, are more likely to be widely adopted in the endemic phase of COVID-19.

Jensen et al. (2025) studied this question.

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September 10, 2025DiagnosticsOpen Access

View Full Paper

Ask AI

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Authors

Comparative analysis reveals saliva shows high sensitivity and specificity, while viral dynamics differ in symptomatic individuals.

The saliva test demonstrated a 94% positive percent agreement and 99% negative percent agreement compared to nasal swabs.
Viral load analysis indicated saliva samples decreased beyond day 1, while nasal swabs increased up to day 4 before decreasing.
Among 737 symptomatic participants, the same number of discordant positive samples was found for saliva and nasal swabs within 5 days of symptom onset.
Testing methods that are less invasive, like saliva-based testing, are more likely to be widely adopted in the endemic phase of COVID-19.

Jensen et al. (2025) studied this question.

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