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December 8, 2025Journal of Nutrition and MetabolismOpen Access

Intestinal ZIP8 Regulates Tissue Manganese Distribution and Modifies Manganese Overload in ZIP14 Deficiency

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Authors

YWYuze WuNZNing-ning Zhao

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Overview

Investigation shows ZIP8 regulates manganese levels in female double knockout mice with implications for overload.

Key Points

  • To clarify the function of intestinal ZIP8 in manganese regulation and its effects in ZIP14 deficiency.
  • Used intestine-specific Zip8 knockout mice and a manganese overload model.
  • Generated double knockout mice by crossing Zip8-I-KO and Zip14-/- mice.
  • Localized ZIP8 in the apical membrane of Caco-2 cells.
  • Intestinal ZIP8 did not affect blood manganese levels under basal conditions.
  • Deletion reduced manganese concentrations in the liver and bone.
  • In female double knockout mice, blood and brain manganese levels declined; no changes were observed in males.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c3f1https://doi.org/10.1155/jnme/6717314
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Also Consider

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