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September 5, 2025Poultry ScienceOpen Access

Effects of silencing or overexpression of ZIP3 and ZIP5 on zinc absorption as zinc sulfate or zinc proteinate and related gene expressions in primary duodenal epithelial cells of broilers

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Authors

CCChunyu CaoYHYun HuLHLiang Huang

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Overview

Experiments reveal zinc absorption differences with ZIP3 and ZIP5 alterations in broiler duodenal cells, indicating their distinct roles in zinc uptake.

Key Points

  • ZIP5 silencing significantly reduced zinc absorption, particularly with zinc proteinate, enhancing its role in uptake.
  • Both ZIP3 and ZIP5 show differing responses to zinc sulfate and zinc proteinate in broiler duodenal cells, crucial for nutrient absorption.
  • Overexpression of ZIP3 or ZIP5 impacted zinc absorption differently, with zinc proteinate showing greater enhancement when ZIP5 is elevated.
  • The data demonstrate specific gene expression alterations affecting zinc absorption, emphasizing the roles of ZIP3 and ZIP5 in nutrient uptake.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477ae4ahttps://doi.org/10.1016/j.psj.2025.105755
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Also Consider

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  1. 1Zinc methionine mitigates intestinal mucosal injury of broilers challenged with Salmonella by modulating mucus secretion, tight junction and microbial composition2025
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  3. 3Effects of dietary supplementation of organic and inorganic zinc on the performance characteristics, tissue mineralization, apparent mineral retention, and antioxidant status of broiler chicks2025 · 5 citations
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