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December 8, 2025Future Journal of Pharmaceutical SciencesOpen Access

Synthesis and anti-inflammatory, analgesic, and anti-ulcerogenic bioevaluation of new indole bioconjugates

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Authors

VRV. Krishna ReddyVBVasudha Bakshi

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Overview

Newly synthesized indole bioconjugates demonstrate anti-inflammatory and analgesic activities, indicating their potential for therapeutic use.

Key Points

  • The study aims to synthesize new indole bioconjugates and evaluate their pharmacological effects.
  • Designed and synthesized N-(3-(1H-indol-5-yl) phenyl) derivatives and (4-(1H-indol-5-yl)piperazin-1-yl)(phenyl)methanone derivatives.
  • Conducted anti-inflammatory tests using the carrageenan-induced paw edema model and analgesic assessment via the hot plate method.
  • Performed molecular docking studies to assess binding affinities to the human cyclooxygenase-2 enzyme.
  • Compounds 5a–5j and 9a–9j showed significant anti-inflammatory effects based on the carrageenan model.
  • Compounds 5f and 5j exhibited the strongest anti-inflammatory and analgesic effects.
  • Compounds 5f and 5j provided excellent protection against gastric mucosal damage, with ulcer inhibition rates of about 92%.

Cite This Study

Reddy et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c3eehttps://doi.org/10.1186/s43094-025-00905-4
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