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January 6, 2026ChemistrySelect

Synthesis, Characterization, Biological Evaluations, and Computational Analysis of Some 6‐Methoxy‐2,3‐Dihydro‐1H‐Inden‐1‐One Derivatives for Analgesic and Anti‐inflammatory Activity

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Authors

VRV. Krishna ReddySBSavita BelwalRBRam Bhavani

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Overview

Novel analgesic and anti‐inflammatory compounds show promise compared to NSAIDs, suggesting future therapeutic potential.

Key Points

  • The aim is to evaluate novel derivatives of 6‐methoxy‐2,3‐dihydro‐1H‐inden‐1‐one for analgesic and anti‐inflammatory activity.
  • Synthesis and characterization of derivatives using NMR and mass spectrometry
  • Evaluation of anti‐inflammatory activity via the carrageenan‐induced rat paw edema model
  • Molecular docking studies to assess binding interactions with ROR (gamma) receptor
  • Compound D8 showed 65% reduction in paw edema, while E8 displayed 54% at 3 h post-treatment
  • Indomethacin had a 72% inhibition of paw edema
  • D8 exhibited a pain response latency increase of 10.11 s, comparable to morphine's 13.12 s

Cite This Study

Reddy et al. (2026) studied this question.

synapsesocial.com/papers/695d856e3483e917927a522bhttps://doi.org/10.1002/slct.202504811
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