Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Journal of Earth Kingdom

In silico development and evaluation of pyruvic acid derivatives as potential analgesic and anti-inflammatory agents

View Full Paper
Ask AI
Bookmark
Share

Authors

AKAryadi Kurniawan

Discussion

Loading...

Member takes

Overview

This research demonstrates the in silico development of pyruvic acid derivatives targeting COX-2, suggesting potential analgesic and anti-inflammatory benefits.

Key Points

  • Compound H6 and H8 showed optimal characteristics, supporting their development as analgesic agents.
  • Molecular docking revealed superior binding affinities for several pyruvic acid derivatives compared to paracetamol.
  • Toxicity profiles predicted lower risks for compounds H8 and H10, highlighting their potential as safer alternatives.
  • All tested derivatives met drug-likeness criteria, indicating they could progress in the drug development pipeline.

Cite This Study

Aryadi Kurniawan (2025) studied this question.

synapsesocial.com/papers/68c23965b210217d6477b5fdhttps://doi.org/10.61511/jek.v3i1.2025.1974
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, Synthesis, In Silico Docking, Multitarget Bioevaluation and Molecular Dynamic Simulation of Novel Pyrazolo[3,4-d]Pyrimidinone Derivatives as Potential In Vitro and In Vivo Anti-Inflammatory Agents2025 · 6 citations
  2. 2Synthesis and anti-inflammatory, analgesic, and anti-ulcerogenic bioevaluation of new indole bioconjugates2025
  3. 3Exploring Potential COX‐2 Inhibitors of Ibuprofen Derivatives: Integrating DFT, Molecular Docking, Molecular Dynamics Simulations, ADMET with FEL and MMPBSA Analyses2025 · 9 citations
  4. 4Synthesis, Characterization, Biological Evaluations, and Computational Analysis of Some <i>6‐Methoxy‐2,3‐Dihydro‐1H‐Inden‐1‐One</i> Derivatives for Analgesic and Anti‐inflammatory Activity2026
  5. 5In silico study of the anti-inflammatory potential of new thiopyrimidine derivatives with 1,2,4-triazole as inhibitors of key inflammatory targets2025