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December 8, 2025npj Antimicrobials and ResistanceOpen Access

Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA

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Authors

CSCaleb Skow

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Overview

Laboratory model indicates bacterial conjugation is regulated by host factors and small RNAs in chickens, suggesting implications for resistance transfer.

Key Points

  • To investigate how host genetics and small RNAs from chicken intestinal tissue regulate bacterial plasmid conjugation.
  • Employs an explant model using chicken ceca tissue samples from commercial and heritage birds.
  • Evaluates the impact of chicken host small RNAs on plasmid transfer between different E. coli strains.
  • Assesses both donor and recipient bacterial populations in vitro.
  • Identifies a bactericidal effect of chicken intestinal tissues on E. coli strains.
  • Demonstrates variable bacterial conjugation related to different host genetic backgrounds.
  • Finds correlation between small RNAs and increased bacterial plasmid conjugation.

Cite This Study

Caleb Skow (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c2echttps://doi.org/10.1038/s44259-025-00163-7
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