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August 18, 2025Microbiology SpectrumOpen Access

Commensal Escherichia coli inhibits the growth and modulates the fitness, virulence, and antimicrobial resistance of Salmonella Heidelberg in vitro

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Authors

YKYasir KhanLELekshmi K. EdisonTDThomas Denagamage

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Overview

Co-culture reveals commensal E. coli impacts virulence and AMR in Salmonella Heidelberg, suggesting new poultry safety approaches.

Key Points

  • Commensal E. coli significantly reduced the growth and virulence of Salmonella Heidelberg, improving food safety.
  • The analysis identified 4,890 differentially expressed genes in Salmonella when co-cultured with E. coli strains.
  • This observational analysis of transcriptomes highlighted reductions in AMR gene expression in Salmonella Heidelberg.
  • These findings suggest E. coli could be a viable option to control antibiotic-resistant Salmonella in poultry settings.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68af2eeacf1dd9ea359e6a8bhttps://doi.org/10.1128/spectrum.03336-24
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