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December 8, 2025Frontiers in EndocrinologyOpen Access

Can vitamin D supplementation be dangerous? 25-Hydroxyvitamin D and 1,25-hydroxyvitamin D concentration in healthy population and primary hyperparathyroidism: a single-center experience and literature review

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Authors

MRMarcin Renke

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Overview

Primary hyperparathyroidism patients show higher vitamin D activation ratio, indicating potential risks.

Key Points

  • To assess the relationship between vitamin D levels and primary hyperparathyroidism outcomes.
  • Analyzed patient groups with primary hyperparathyroidism and a control group without calcium imbalance.
  • Divided patients into subgroups based on treatment approach: conservative or surgical.
  • Measured serum concentrations of PTH, calcium, phosphates, and vitamin D forms.
  • Significantly higher 1,25-OH-D levels observed in surgical candidates.
  • VD-AR higher in surgical group, correlating with hypercalcemia risks.
  • Establishment of a VD-AR cut-off value of 3.3 as clinically relevant.

Cite This Study

Marcin Renke (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c140https://doi.org/10.3389/fendo.2025.1700345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preoperative 25(OH)D≥75 Nmol/L is associated with a reduced risk of hypocalcemia after parathyroidectomy: evidence from a meta-analysis2025
  2. 2A-075 Distinguishing Secondary Hyperparathyroidism from Early Normocalcemic Primary Hyperparathyroidism: Does Selection of Reference Change Values Change the Clinical Significance of Diagnostic Outcomes?2025
  3. 3Relationship Between Total 25-Hydroxyvitamin D and Parathyroid Hormone Concentrations During Early Gestation in Indian Women.2025
  4. 4Immunohistochemical Expression of CaSR, VDR, and AMA in Parathyroid Tumors Linked to Hypercalcemia Severity in Primary Hyperparathyroidism2025
  5. 5Extended-Release Calcifediol Identifies a Therapeutic Vitamin D Range in Chronic Kidney Disease stage 3-42026