Meta-analysis reveals preoperative vitamin D levels ≥75 nmol/L reduce hypocalcemia risk in primary hyperparathyroidism patients, suggesting effective prevention strategies.
Key Points
To evaluate the necessity of preoperative 25(OH)D levels for reducing hypocalcemia risk after parathyroidectomy in patients with primary hyperparathyroidism.
Conducted a meta-analysis of eight observational studies involving 4,120 patients.
Systematically searched databases for studies assessing preoperative 25(OH)D levels and hypocalcemia outcomes.
Data extraction focused on study design characteristics, baseline vitamin D, calcium, and PTH levels.
Patients with preoperative 25(OH)D ≥75 nmol/L had a 44% lower risk of hypocalcemia postoperatively (RR 0.56).
No significant hypocalcemia risk reduction in patients with 25(OH)D levels 50–75 nmol/L compared to levels <50 nmol/L (RR 0.65).
Maintaining 25(OH)D levels ≥75 nmol/L did not correlate with increased preoperative serum calcium levels.