Propofol Alleviates Depression‐Like Behavior and Cognitive Disorder in Learned Helplessness Model Mice via Regulating Synaptic Function

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Propofol alleviated depression-like behavior and cognitive deficits in a learned helplessness model.
Mice treated with propofol displayed enhanced synaptic plasticity and neurogenesis, highlighting its neuroprotective effects.
Assessment included various behavioral analyses, including the tail suspension test for evaluating depression-like behaviors.
Findings indicate that propofol may serve as an effective antidepressant with mechanisms linked to the Notch signaling pathway.

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Treatment with propofol improved depression-like symptoms and synaptic function in C57BL/6j mice, suggesting novel antidepressant properties.

Wang et al. (2025) studied this question.

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Treatment with propofol improved depression-like symptoms and synaptic function in C57BL/6j mice, suggesting novel antidepressant properties.