Ciprofol Alleviates Depressive-Like Behaviors in CUMS Mice Through PPARα-Associated ERK/CREB Signaling Activation

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Ciprofol treatment significantly reduced depressive-like behaviors in mice exposed to chronic unpredictable mild stress.
Mice receiving ciprofol showed less immobility and increased sucrose preference, indicating improved mood.
The antidepressant effects appear linked to PPARα activation and the ERK/CREB signaling pathway.
Ciprofol also suppressed neuroinflammation and preserved synaptic integrity in the prefrontal cortex.

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Intravenous ciprofol improves depressive-like behaviors in CUMS mice, suggesting PPARα and ERK/CREB involvement.

Li et al. (2025) studied this question.

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