Prolonged blockade of NMDA receptors and positive modulation of a5 GABA A receptors: No changes in depressive-like behavior, while the former slightly increased emotional reactivity in unstressed rats

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No change in depressive-like behavior was observed in treated rats, indicating possible resistance to these interventions.
Behavioral tests revealed that ketamine (10 mg/kg) increased emotional reactivity, while lower doses did not show significant effects.
The study involved adult male Sprague-Dawley rats given either ketamine or GL-II-73 in a controlled experimental setting over seven days.
These findings suggest that while certain treatments may affect emotional reactivity, they may not directly alter depressive-like behavior in this model.

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Repeated ketamine and GL-II-73 treatment showed no change in depressive-like behaviors in rats, suggesting subtle effects on emotional response.

Djorović et al. (2025) studied this question.

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Repeated ketamine and GL-II-73 treatment showed no change in depressive-like behaviors in rats, suggesting subtle effects on emotional response.