Analysis reveals diminished regulatory T cells in primary Sjögren’s syndrome, suggesting impaired survival and Treg apoptosis.
Key Points
The abundance of regulatory T cells is significantly reduced in patients with primary Sjögren’s syndrome, indicating a possible link to disease severity.
Transcriptome sequencing identified 187 upregulated and 674 downregulated genes in Tregs, highlighting enhanced apoptosis in this condition.
A combination of flow cytometry and immunohistochemistry techniques confirmed apoptosis within Treg populations specifically in salivary gland tissue.
Investigating ways to enhance regulatory T cell levels may open new avenues for targeted therapies in primary Sjögren’s syndrome.