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December 4, 2025EMBO Molecular MedicineOpen Access

Corneal biomechanical cues mediated by PAI-2: the origin of PM2.5-induced corneal disease

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Authors

SHShengjie HaoDLDan LiLCLu Chen

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Overview

Evidence shows altered corneal hysteresis and thickness in response to PM2.5, suggesting PAI-2 may serve as a biomarker for early intervention.

Key Points

  • Corneal hysteresis and thickness increased with PM2.5 exposure, indicating early mechanical damage.
  • Intracellular PAI-2 mediates autophagy and inflammation, essential for understanding corneal disease.
  • Analysis utilized human, rat, and HCEC models to highlight biomechanical responses to PM2.5.
  • Results support PAI-2 as a potential biomarker for diagnosing corneal damage from PM2.5 exposure.

Cite This Study

Hao et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a94https://doi.org/10.1038/s44321-025-00341-0
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Also Consider

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  1. 1Corneal Biomechanics and Their Impact on Glaucoma Progression2023
  2. 2Is keratoconus limited to the cornea? A prospective analysis of corneal biomechanics using corneal visualisation Scheimpflug technology.2025
  3. 3Real-Life Assessment of Multi-Pollutant Exposure and Its Impact on the Ocular Surface: The Bike-Eye Pilot Study on Urban Cyclists in Bologna2025
  4. 4PM2.5 exposure induces transcriptomic changes in ARPE-19 cells with activation of TGFβ-mediated signaling pathways: A next-generation sequencing approach2025
  5. 5Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers2025