PM2.5 exposure induces transcriptomic changes in ARPE-19 cells with activation of TGFβ-mediated signaling pathways: A next-generation sequencing approach

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Next-generation sequencing reveals that PM2.5 exposure enhances cellular migration in ARPE-19 cells, highlighting TGFβ signaling pathways.

PM2.5 exposure significantly enhanced ARPE-19 cell migration and viability, indicating environmental impacts on ocular health.
Next-generation sequencing discovered that TGFβ, MAPK, and PI3K/AKT signaling pathways were activated after PM2.5 exposure.
Bioinformatic analyses indicated that ANGPTL4 was notably upregulated, serving as a downstream effector in TGFβ signaling.
Pharmacological inhibition of TGFβ signaling reduced PM2.5-induced ANGPTL4 expression, emphasizing its role in retinal responses.

Chen et al. (2025) studied this question.

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Next-generation sequencing reveals that PM2.5 exposure enhances cellular migration in ARPE-19 cells, highlighting TGFβ signaling pathways.

PM2.5 exposure significantly enhanced ARPE-19 cell migration and viability, indicating environmental impacts on ocular health.
Next-generation sequencing discovered that TGFβ, MAPK, and PI3K/AKT signaling pathways were activated after PM2.5 exposure.
Bioinformatic analyses indicated that ANGPTL4 was notably upregulated, serving as a downstream effector in TGFβ signaling.
Pharmacological inhibition of TGFβ signaling reduced PM2.5-induced ANGPTL4 expression, emphasizing its role in retinal responses.

Chen et al. (2025) studied this question.

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