Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Cornea

Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers

View Full Paper
Ask AI
Bookmark
Share

Authors

JDJorge Luis Domene-HickmanLHLuis Haro-MorlettGVGuillermo Raúl Vera-Duarte

Discussion

Loading...

Member takes

Implication

Case series assessed biomechanical indices in p.Ala546Asp mutation carriers, revealing early changes suggesting instability.

Key Points

  • Mutation carriers showed significantly higher corneal biomechanical index (CBI), regardless of visible deposits.
  • Stiffness parameter at first applanation (SP-A1) was significantly lower in mutation carriers, pointing to altered corneal stiffness.
  • Biomechanical changes occurred before clinical deposits formed, indicating early instability linked to the mutation.
  • Findings support biomechanical assessment as a tool for detecting subclinical changes in granular corneal dystrophy type 2.

Cite This Study

Domene-Hickman et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787b47https://doi.org/10.1097/ico.0000000000003981
View Full Paper
Ask AI
Bookmark
Share