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December 4, 2025NAR Molecular MedicineOpen Access

Genome-wide evolutionary selection pressures acting on Pseudomonas aeruginosa residing in different environments

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Authors

PHPok-Man HoRNRahan Rudland NazeerMWMartin Welch

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Overview

Analysis reveals negative selection in cystic fibrosis isolates of Pseudomonas aeruginosa, implying distinct evolutionary paths from environmental strains.

Key Points

  • Negative selection was observed in a majority of open reading frames of Pseudomonas aeruginosa in cystic fibrosis isolates, highlighting conservation.
  • Functional analysis indicated that specific genes under selection pressure are enriched in metabolic branchpoints in cystic fibrosis.
  • Evaluating evolutionary selection pressures involved analyzing dN/dS ratios in CF-associated versus environmental isolates of Pseudomonas aeruginosa.
  • This work emphasizes niche-specific adaptations in pathogenic bacteria, necessitating further study of gene loss and regulatory mutations.

Cite This Study

Ho et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca218fhttps://doi.org/10.1093/narmme/ugaf040
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