Activation of the glp regulon decreases antibiotic susceptibility and alters virulence in Pseudomonas aeruginosa, suggesting a role in chronic infections.
Key Points
Loss of GlpR leads to reduced tobramycin susceptibility in Pseudomonas aeruginosa isolates, contributing to antibiotic resistance.
Transcriptomics reveals that CF-adapted mutants overexpress multidrug resistance genes and virulence factors like alginate.
Increased biofilm development is associated with the loss of GlpR, enhancing Pseudomonas aeruginosa's ability to persist in the airway.
Findings suggest that targeting the glycerol regulon could be a therapeutic strategy against chronic infections in cystic fibrosis.