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August 15, 2025Advances in Laboratory Medicine / Avances en Medicina de LaboratorioOpen Access

Genomic characterization of Pseudomonas aeruginosa adaptation mechanisms in bronchiectasis patients

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Authors

ASAlba Muñoz SantaXGXavier Gómez‐ArbonésRTRicardo Pifarré Teixidó

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Overview

Analysis reveals antibiotic susceptibility patterns in Pseudomonas aeruginosa from bronchiectasis patients, suggesting adaptation mechanisms.

Key Points

  • Pseudomonas aeruginosa adapts through loss-of-function mutations, impacting antibiotic resistance and motility.
  • Among 100 isolates from bronchiectasis patients, specific mutations were linked to antibiotic susceptibility profiles.
  • Whole genome sequencing identified key adaptation genes, including those for efflux pumps and motility.
  • These findings may inform alternative treatment strategies for chronic bronchial infections.

Cite This Study

Santa et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1d76https://doi.org/10.1515/almed-2025-0044
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