November 28, 2025Brain and BehaviorOpen Access

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

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Authors

JYJiang Yan YZYuxiang Zhang LMLei Ma

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Implication

Genome-wide analysis reveals genetic correlations between gastrointestinal and neurodegenerative diseases, indicating shared pathways and therapeutic targets.

Key Points

Significant genetic correlations were identified between gastrointestinal diseases and neurodegenerative diseases.
The analysis revealed 1,457 pleiotropic variants, with key genes like EP300 involved in shared pathways.
Assessment utilized genome-wide association study data and two-sample Mendelian randomization techniques.
Findings support a gut-brain axis, offering potential therapeutic targets in both disease types.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a7bc https://doi.org/10.1002/brb3.71029

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Implication

Genome-wide analysis reveals genetic correlations between gastrointestinal and neurodegenerative diseases, indicating shared pathways and therapeutic targets.

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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