Analysis reveals significant genetic correlations and identifies pathogenic cell types in Alzheimer's disease and inflammatory bowel disease.
Key Points
Pathogenic cell types identified are monocytes for Alzheimer's disease and CD8 T cells for inflammatory bowel disease.
A significant global genetic correlation was found between Alzheimer's disease and inflammatory bowel disease, including ulcerative colitis and Crohn's disease.
New shared genetic loci rs660895 and rs917117 were identified, located on genes HLA-DRB1 and JAZF1, respectively.
Pathway enrichment analysis highlighted that shared genes are involved in natural killer cell mediated cytotoxicity and chemokine signaling.