November 28, 2025Molecular Reproduction and DevelopmentOpen Access

The Transcriptional Regulator FOXR1 Is Required for Normal Early Embryogenesis but Dispensable for Male Fertility in Mice

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SJSoazik P Jamin FPFabrice G. Petit CKChristine Kervarrec

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Implication

Gene deletion analysis reveals that foxr1 is vital for embryo development in mice, but male fertility remains normal, suggesting functional redundancy in gonads.

Key Points

Transcription factors play a crucial role in regulating early embryogenesis, indicating their importance in development.
The disruption of foxr1 resulted in embryonic lethality in mice, while male fertility was unaffected.
Analysis of genomic data highlighted foxr1's involvement in brain development and potential oncogenic effects as a fusion gene.
These findings emphasize the dichotomy of functional roles for foxr1 during development and adult male reproduction.

Cite This Study

Jamin et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a151 https://doi.org/10.1002/mrd.70071

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Implication

Gene deletion analysis reveals that foxr1 is vital for embryo development in mice, but male fertility remains normal, suggesting functional redundancy in gonads.

The Transcriptional Regulator FOXR1 Is Required for Normal Early Embryogenesis but Dispensable for Male Fertility in Mice

Discussion

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Implication

Key Points

Cite This Study

The Transcriptional Regulator FOXR1 Is Required for Normal Early Embryogenesis but Dispensable for Male Fertility in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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