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November 25, 2025International Journal of GenomicsOpen Access

Single‐Cell RNA Sequencing Reveals the Therapeutic Effects of Electroacupuncture at BL23 on Hyperuricemia‐Induced Nephritis

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Authors

YHYiyang HuXSXue-Yan SongHLHaichang Li

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Overview

Electroacupuncture shows therapeutic benefits on kidney inflammation in mice with hyperuricemia, indicating immune system modulation.

Key Points

  • To investigate the effects of electroacupuncture at BL23 on hyperuricemia and HUA-induced kidney inflammation in mice.
  • Mice were given intragastric potassium oxonate and adenine to induce hyperuricemia.
  • Electroacupuncture was administered daily to the mice.
  • Serum and kidney samples were analyzed for uric acid and cytokine levels.
  • ScRNA-seq was performed on treated kidneys to assess cellular changes.
  • Electroacupuncture reduced serum uric acid and blood urea nitrogen levels.
  • The treatment decreased inflammatory cytokines including IL-6.
  • EA promoted autophagy and inhibited the NLRP3 inflammasome complex.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/692502d187af00ed34ac291chttps://doi.org/10.1155/ijog/2494933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Electroacupuncture at Zusanli improves blood lipid disorders in hyperlipidemic mice by improving gut microbiota structure].2025 · 2 citations
  2. 2Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression2025
  3. 3Electroacupuncture Attenuates Hepatic Ischemia‐Reperfusion Injury by Modulating the Esr1/TAK1–JNK/p38 Signaling Pathway in Rats2025
  4. 4Therapeutic effect of fecal microbiota transplantation on hyperuricemia mice by improving gut microbiota2025
  5. 5Electroacupuncture at Huantiao (GB30) and Zusanli (ST36) acupoints promotes peripheral nerve regeneration by enhancing energy metabolism in mice2025