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October 27, 2025CancerOpen Access

Optimizing Wilms tumor 1 thresholds for measurable residual disease monitoring in acute myeloid leukemia: Improved sensitivity and concordance with nucleophosmin 1 in a single‐center validation study

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Authors

SBSabrina BarrièreCBCéline BourgneTTThomas Tassin

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Overview

Validation study shows improved prognostic value and sensitivity of WT1 monitoring in acute myeloid leukemia, highlighting its clinical significance.

Key Points

  • The revised WT1 threshold of seven copies improves prognostic value in acute myeloid leukemia with higher sensitivity.
  • This study demonstrates a 78.6% concordance rate with Nucleophosmin 1 mutations, indicating better MRD monitoring.
  • Statistical analyses employed include concordance, sensitivity, specificity, and Akaike information criterion comparisons.
  • Findings emphasize the importance of locally optimized thresholds for measurable residual disease in acute myeloid leukemia.

Cite This Study

Barrière et al. (2025) studied this question.

synapsesocial.com/papers/68ff87d8c8c50a61f2bdccadhttps://doi.org/10.1002/cncr.70140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-induction minimal residual disease assessment by flow cytometry and molecular biology enables prognostic stratification of patients with NPM1-mutated Acute Myeloid Leukemia: A dataml registry study.2025
  2. 2A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  3. 3Comparative evaluation of NGS-based MRD detection in AML using longitudinal matched bone marrow and blood samples2025
  4. 4Low levels of wilms tumor 1 (WT1) protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia2025
  5. 5Prognostic covariates associated with outcomes in patients with <i>NPM1</i>-mutated acute myeloid leukemia2025 · 3 citations